Recent advances in genome editing technology have allowed scientists to manipulate genome sequences quickly and efficiently. Despite the revolutionary advances in this field, several challenges remain. Existing gene editing technologies such as CRISPR-cas9, core editors and core editors have great potential. Yet, existing delivery technologies cannot deliver gene editing technologies to many target tissues and cell types in sufficient quantities, hampering clinical applications. While some cell types, such as liver hepatocytes, have numerous delivery technologies capable of delivering genome editors, many other organs and cell types are more difficult to reach.
The Challenge is a competition in three phases:
During Phase 1, participants will be invited to submit a proposal describing the proposed solution and how it will meet the requirements of one of the target areas. Participants may submit solution proposals for both target areas, but must do so with separate proposals that independently address the requirements of each target area. Up to ten proposals deemed to meet the best requirements will each receive up to $75,000. Additional prizes of $50,000 may be awarded to additional meritorious solutions based on the judging criteria.
In Phase 2, participants must submit data from studies demonstrating delivery and publishing performance and describe their methodology, technology, and how their solution meets the challenge criteria. Participation in Phase 1 is not a requirement to participate in Phase 2; however, it is strongly encouraged. Up to 10 Phase 2 winners will each receive $250,000 and will be eligible to participate in Phase 3. Only Phase 2 winners will be eligible to participate in Phase 3.
Phase 3 is separated into phase 3a and phase 3b; All participants must submit solutions for Phase 3a to be eligible to participate in Phase 3b. For Phase 3a, participants must submit all required information demonstrating that their technology is ready for large animal testing through independent evaluation supported by the NIH and can meet the requirements of one of the target areas .
Entries for this challenge must be received by 00:00 EET, January 11, 2025.
Source: Challenge.gov
Originally published in The European Times.
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