Caspase 5c amplifies Wnt via APC cleavage to promote intestinal homeostasis

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Barnett, K. C., Li, S., Liang, K. & Ting, J. P. A. 360 degrees view of the inflammasome: mechanisms of activation, cell death, and diseases. Cell 186, 2288–2312 (2023).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Green, D. R. Caspases and their substrates. Cold Spring Harb. Perspect. Biol. 14, a041012 (2022).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Kesavardhana, S., Malireddi, R. K. S. & Kanneganti, T. D. Caspases in cell death, inflammation, and pyroptosis. Annu. Rev. Immunol. 38, 567–595 (2020).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Eckhart, L. & Fischer, H. Caspase-5: structure, pro-inflammatory activity and evolution. Biomolecules 14, 520 (2024).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Herrmann, B. I., Grayczyk, J. P. & Brodsky, I. E. Collab or cancel? Bacterial influencers of inflammasome signaling. Annu. Rev. Microbiol. 77, 451–477 (2023).

Article 
CAS 
PubMed 

Google Scholar 

Ross, C. et al. Inflammatory caspases: toward a unified model for caspase activation by inflammasomes. Annu. Rev. Immunol. 40, 249–269 (2022).

Article 
CAS 
PubMed 

Google Scholar 

Gehart, H. & Clevers, H. Tales from the crypt: new insights into intestinal stem cells. Nat. Rev. Gastroenterol. Hepatol. 16, 19–34 (2019).

Article 
PubMed 

Google Scholar 

Rim, E. Y., Clevers, H. & Nusse, R. The Wnt pathway: from signaling mechanisms to synthetic modulators. Annu. Rev. Biochem. 91, 571–598 (2022).

Article 
CAS 
PubMed 

Google Scholar 

Beumer, J. & Clevers, H. Cell fate specification and differentiation in the adult mammalian intestine. Nat. Rev. Mol. Cell Biol. 22, 39–53 (2021).

Article 
CAS 
PubMed 

Google Scholar 

Shi, J. et al. Inflammatory caspases are innate immune receptors for intracellular LPS. Nature 514, 187–192 (2014).

Article 
CAS 
PubMed 
ADS 

Google Scholar 

Sander, L. E. et al. Detection of prokaryotic mRNA signifies microbial viability and promotes immunity. Nature 474, 385–389 (2011).

Article 
CAS 
PubMed 
PubMed Central 
ADS 

Google Scholar 

Moretti, J. et al. Caspase-11 interaction with NLRP3 potentiates the noncanonical activation of the NLRP3 inflammasome. Nat. Immunol. 23, 705–717 (2022).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Holland, M., Rutkowski, R. & Levin, T. C. Evolutionary dynamics of proinflammatory caspases in primates and rodents. Mol. Biol. Evol. 41, msae220 (2024).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Uhlen, M. et al. Tissue-based map of the human proteome. Science 347, 1260419 (2015).

Article 
PubMed 

Google Scholar 

Lin, X. Y., Choi, M. S. & Porter, A. G. Expression analysis of the human caspase-1 subfamily reveals specific regulation of the CASP5 gene by lipopolysaccharide and interferon-gamma. J. Biol. Chem. 275, 39920–39926 (2000).

Article 
CAS 
PubMed 

Google Scholar 

Casson, C. N. et al. Human caspase-4 mediates noncanonical inflammasome activation against gram-negative bacterial pathogens. Proc. Natl Acad. Sci. USA 112, 6688–6693 (2015).

Article 
CAS 
PubMed 
PubMed Central 
ADS 

Google Scholar 

Naseer, N. et al. Salmonella enterica serovar Typhimurium induces NAIP/NLRC4- and NLRP3/ASC-independent, caspase-4-dependent inflammasome activation in human intestinal epithelial cells. Infect. Immun. 90, e0066321 (2022).

Article 
PubMed 
PubMed Central 

Google Scholar 

Gao, C. & Chen, Y. G. Dishevelled: The hub of Wnt signaling. Cell Signal 22, 717–727 (2010).

Article 
CAS 
PubMed 

Google Scholar 

Sharma, M., Castro-Piedras, I., Simmons, G. E. Jr & Pruitt, K. Dishevelled: a masterful conductor of complex Wnt signals. Cell Signal 47, 52–64 (2018).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Exconde, P. M. et al. The tetrapeptide sequence of IL-18 and IL-1β regulates their recruitment and activation by inflammatory caspases. Cell Rep. 42, 113581 (2023).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Nusse, R. & Clevers, H. Wnt/β-catenin signaling, disease, and emerging therapeutic modalities. Cell 169, 985–999 (2017).

Article 
CAS 
PubMed 
ADS 

Google Scholar 

Bankaitis, E. D., Ha, A., Kuo, C. J. & Magness, S. T. Reserve stem cells in intestinal homeostasis and injury. Gastroenterology 155, 1348–1361 (2018).

Article 
PubMed 
PubMed Central 

Google Scholar 

Shivdasani, R. A., Clevers, H. & de Sauvage, F. J. Tissue regeneration: reserve or reverse? Science 371, 784–786 (2021).

Article 
CAS 
PubMed 
ADS 

Google Scholar 

Sprangers, J., Zaalberg, I. C. & Maurice, M. M. Organoid-based modeling of intestinal development, regeneration, and repair. Cell Death Differ. 28, 95–107 (2021).

Article 
PubMed 

Google Scholar 

Xie, G. et al. Zinc finger protein 277 is an intestinal transit-amplifying cell marker and colon cancer oncogene. JCI Insight 7, e150894 (2022).

Article 
PubMed 
PubMed Central 

Google Scholar 

Ayyaz, A. et al. Single-cell transcriptomes of the regenerating intestine reveal a revival stem cell. Nature 569, 121–125 (2019).

Article 
CAS 
PubMed 
ADS 

Google Scholar 

Chi, Z. et al. Gasdermin D-mediated metabolic crosstalk promotes tissue repair. Nature 634, 1168–1177 (2024).

Article 
CAS 
PubMed 
ADS 

Google Scholar 

Wong, H. C. et al. Structural basis of the recognition of the dishevelled DEP domain in the Wnt signaling pathway. Nat. Struct. Biol. 7, 1178–1184 (2000).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Li, V. S. et al. Wnt signaling through inhibition of beta-catenin degradation in an intact Axin1 complex. Cell 149, 1245–1256 (2012).

Article 
CAS 
PubMed 

Google Scholar 

Lamkanfi, M. & Dixit, V. M. Inflammasomes and their roles in health and disease. Annu. Rev. Cell Dev. Biol. 28, 137–161 (2012).

Article 
CAS 
PubMed 

Google Scholar 

Riedl, S. J. & Salvesen, G. S. The apoptosome: signalling platform of cell death. Nat. Rev. Mol. Cell Biol. 8, 405–413 (2007).

Article 
CAS 
PubMed 

Google Scholar 

Shi, J. et al. Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death. Nature 526, 660–665 (2015).

Article 
CAS 
PubMed 
ADS 

Google Scholar 

Akuma, D. C. et al. Catalytic activity and autoprocessing of murine caspase-11 mediate noncanonical inflammasome assembly in response to cytosolic LPS. eLife 13, e83725 (2024).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Fodde, R., Smits, R. & Clevers, H. APC, signal transduction and genetic instability in colorectal cancer. Nat. Rev. Cancer 1, 55–67 (2001).

Article 
CAS 
PubMed 

Google Scholar 

Zhang, L. & Shay, J. W. Multiple roles of APC and its therapeutic implications in colorectal cancer. J. Natl Cancer Inst. 106, djw332 (2017).

Google Scholar 

Cancer Genome Atlas, N. Comprehensive molecular characterization of human colon and rectal cancer. Nature 487, 330–337 (2012).

Article 
ADS 

Google Scholar 

Guinney, J. et al. The consensus molecular subtypes of colorectal cancer. Nat. Med. 21, 1350–1356 (2015).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Schwartz, S. Jr et al. Frameshift mutations at mononucleotide repeats in caspase-5 and other target genes in endometrial and gastrointestinal cancer of the microsatellite mutator phenotype. Cancer Res. 59, 2995–3002 (1999).

CAS 
PubMed 

Google Scholar 

Tougeron, D. et al. Tumor-infiltrating lymphocytes in colorectal cancers with microsatellite instability are correlated with the number and spectrum of frameshift mutations. Mod. Pathol. 22, 1186–1195 (2009).

Article 
CAS 
PubMed 

Google Scholar 

Smillie, C. S. et al. Intra- and inter-cellular rewiring of the human colon during ulcerative colitis. Cell 178, 714–730 e722 (2019).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Burclaff, J. et al. A proximal-to-distal survey of healthy adult human small intestine and colon epithelium by single-cell transcriptomics. Cell. Mol. Gastroenterol. Hepatol. 13, 1554–1589 (2022).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Elmentaite, R. et al. Cells of the human intestinal tract mapped across space and time. Nature 597, 250–255 (2021).

Article 
CAS 
PubMed 
PubMed Central 
ADS 

Google Scholar 

Flood, B. et al. Altered expression of caspases-4 and -5 during inflammatory bowel disease and colorectal cancer: Diagnostic and therapeutic potential. Clin. Exp. Immunol. 181, 39–50 (2015).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Steen, C. B., Liu, C. L., Alizadeh, A. A. & Newman, A. M. Profiling cell type abundance and expression in bulk tissues with CIBERSORTx. Methods Mol. Biol. 2117, 135–157 (2020).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Li, H. et al. Reference component analysis of single-cell transcriptomes elucidates cellular heterogeneity in human colorectal tumors. Nat. Genet. 49, 708–718 (2017).

Article 
CAS 
PubMed 

Google Scholar 

Triki, M., Lapierre, M., Cavailles, V. & Mokdad-Gargouri, R. Expression and role of nuclear receptor coregulators in colorectal cancer. World J. Gastroenterol. 23, 4480–4490 (2017).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Beumer, J. et al. High-resolution mRNA and secretome atlas of human enteroendocrine cells. Cell 181, 1291–1306.e1219 (2020).

Article 
CAS 
PubMed 

Google Scholar 

Pleguezuelos-Manzano, C. et al. Establishment and culture of human intestinal organoids derived from adult stem cells. Curr. Protoc. Immunol. 130, e106 (2020).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Haramis, A. P. et al. De novo crypt formation and juvenile polyposis on BMP inhibition in mouse intestine. Science 303, 1684–1686 (2004).

Article 
CAS 
PubMed 
ADS 

Google Scholar 

Moparthi, L. & Koch, S. Wnt signaling in intestinal inflammation. Differentiation 108, 24–32 (2019).

Article 
CAS 
PubMed 

Google Scholar 

Kim, D. I. et al. An improved smaller biotin ligase for BioID proximity labeling. Mol. Biol. Cell 27, 1188–1196 (2016).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Veeman, M. T., Slusarski, D. C., Kaykas, A., Louie, S. H. & Moon, R. T. Zebrafish prickle, a modulator of noncanonical Wnt/Fz signaling, regulates gastrulation movements. Curr. Biol. 13, 680–685 (2003).

Article 
CAS 
PubMed 

Google Scholar 

Fuerer, C. & Nusse, R. Lentiviral vectors to probe and manipulate the Wnt signaling pathway. PLoS ONE 5, e9370 (2010).

Article 
PubMed 
PubMed Central 
ADS 

Google Scholar 

Sanjana, N. E., Shalem, O. & Zhang, F. Improved vectors and genome-wide libraries for CRISPR screening. Nat. Methods 11, 783–784 (2014).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Lim, K. L. et al. Parkin mediates nonclassical, proteasomal-independent ubiquitination of synphilin-1: implications for Lewy body formation. J. Neurosci. 25, 2002–2009 (2005).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Viladomiu, M. et al. IgA-coated E. coli enriched in Crohn’s disease spondyloarthritis promote TH17-dependent inflammation. Sci. Transl. Med. 9, eaaf9655 (2017).

Article 
PubMed 
PubMed Central 

Google Scholar 

Sato, T. et al. Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett’s epithelium. Gastroenterology 141, 1762–1772 (2011).

Article 
CAS 
PubMed 

Google Scholar 

Barker, N. et al. Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature 449, 1003–1007 (2007).

Article 
CAS 
PubMed 
ADS 

Google Scholar 

National Research Council of the National Academies. Guide for the Care and Use of Laboratory Animals, 8th Edn (The National Academies Press, 2011).

Jadhav, U. et al. Dynamic reorganization of chromatin accessibility signatures during dedifferentiation of secretory precursors into Lgr5+ intestinal stem cells. Cell Stem Cell 21, 65–77.e65 (2017).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Tabula Muris, C. et al. Single-cell transcriptomics of 20 mouse organs creates a Tabula Muris. Nature 562, 367–372 (2018).

Article 
ADS 

Google Scholar 

Capdevila, C. et al. Time-resolved fate mapping identifies the intestinal upper crypt zone as an origin of Lgr5+ crypt base columnar cells. Cell 187, 3039–3055.e3014 (2024).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Boucher, D. et al. Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity. J. Exp. Med. 215, 827–840 (2018).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Faleiro, L., Kobayashi, R., Fearnhead, H. & Lazebnik, Y. Multiple species of CPP32 and Mch2 are the major active caspases present in apoptotic cells. EMBO J. 16, 2271–2281 (1997).

Article 
CAS 
PubMed 
PubMed Central 
ADS 

Google Scholar 

Dominguez Conde, C. et al. Cross-tissue immune cell analysis reveals tissue-specific features in humans. Science 376, eabl5197 (2022).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Dobin, A. et al. STAR: ultrafast universal RNA-seq aligner. Bioinformatics 29, 15–21 (2013).

Article 
CAS 
PubMed 

Google Scholar 

Li, B. & Dewey, C. N. RSEM: accurate transcript quantification from RNA-seq data with or without a reference genome. BMC Bioinformatics 12, 323 (2011).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Gulati, G. S. et al. Single-cell transcriptional diversity is a hallmark of developmental potential. Science 367, 405–411 (2020).

Article 
CAS 
PubMed 
PubMed Central 
ADS 

Google Scholar 

Chen, E. Y. et al. Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool. BMC Bioinformatics 14, 128 (2013).

Article 
PubMed 
PubMed Central 

Google Scholar 

Xie, Z. et al. Gene set knowledge discovery with Enrichr. Curr. Protoc. 1, e90 (2021).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Liu, Y. et al. Comparative molecular analysis of gastrointestinal adenocarcinomas. Cancer Cell 33, 721–735.e728 (2018).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Newman, A. M. et al. Determining cell type abundance and expression from bulk tissues with digital cytometry. Nat. Biotechnol. 37, 773–782 (2019).

Article 
CAS 
PubMed 
PubMed Central 
ADS 

Google Scholar 

Funk, M. C. et al. Aged intestinal stem cells propagate cell-intrinsic sources of inflammaging in mice. Dev. Cell 58, 2914–2929.e2917 (2023).

Article 
CAS 
PubMed 

Google Scholar 

Edgar, R. C. MUSCLE: multiple sequence alignment with high accuracy and high throughput. Nucleic Acids Res. 32, 1792–1797 (2004).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Kumar, S., Stecher, G., Li, M., Knyaz, C. & Tamura, K. MEGA X: molecular evolutionary genetics analysis across computing platforms. Mol. Biol. Evol. 35, 1547–1549 (2018).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Stecher, G., Tamura, K. & Kumar, S. Molecular Evolutionary Genetics Analysis (MEGA) for macOS. Mol. Biol. Evol. 37, 1237–1239 (2020).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Jones, D. T., Taylor, W. R. & Thornton, J. M. The rapid generation of mutation data matrices from protein sequences. Comput. Appl. Biosci. 8, 275–282 (1992).

CAS 
PubMed 

Google Scholar 

Felsenstein, J. Confidence limits on phylogenies: an approach using the bootstrap. Evolution 39, 783–791 (1985).

Article 
PubMed 

Google Scholar 

Peled, M. et al. Affinity purification mass spectrometry analysis of PD-1 uncovers SAP as a new checkpoint inhibitor. Proc. Natl Acad. Sci. USA 115, E468–E477 (2018).

Article 
CAS 
PubMed 

Google Scholar 

Stirling, D. R. et al. CellProfiler 4: improvements in speed, utility and usability. BMC Bioinformatics 22, 433 (2021).

Article 
PubMed 
PubMed Central 

Google Scholar 

Vincent, L. Granulometries and opening trees. Fundam. Inf. 41, 57–90 (2000).

Google Scholar 

Hepworth, M. R. et al. Immune tolerance. Group 3 innate lymphoid cells mediate intestinal selection of commensal bacteria-specific CD4+ T cells. Science 348, 1031–1035 (2015).

Article 
CAS 
PubMed 
PubMed Central 
ADS 

Google Scholar 

Longman, R. S. et al. CX3CR1+ mononuclear phagocytes support colitis-associated innate lymphoid cell production of IL-22. J. Exp. Med. 211, 1571–1583 (2014).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Kobayashi, T. et al. The Shigella OspC3 effector inhibits caspase-4, antagonizes inflammatory cell death, and promotes epithelial infection. Cell Host Microbe 13, 570–583 (2013).

Article 
CAS 
PubMed 

Google Scholar 

Liu, X. et al. Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores. Nature 535, 153–158 (2016).

Article 
CAS 
PubMed 
PubMed Central 
ADS 

Google Scholar 


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